Nerve Growth Factor Protein (NGF) (AA 122-241) (His tag)

Catalog No. ABIN7505449

Product Details

Target: Nerve Growth Factor (NGF)

Protein Type: Recombinant

Protein Characteristics: AA 122-241

Origin: Mouse

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Nerve Growth Factor protein is labelled with His tag.

Sequence: Ser 122-Gly 241

Characteristics: A DNA sequence encoding the Mouse NGF/NGFB/beta-NGF protein (P01139) (Ser 122-Gly 241) was expressed with N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Nerve Growth Factor (NGF)

Alternative Name: NGF (NGF Products)

Synonyms: Beta-NGF Protein, HSAN5 Protein, NGFB Protein, Ngfb Protein, ngfb Protein, ns:zft386 Protein, xx:zft386 Protein, zgc:109730 Protein, beta-NGF Protein, hsan5 Protein, beta-ngf Protein, NGF Protein, ngf Protein, nerve growth factor Protein, nerve growth factor b (beta polypeptide) Protein, nerve growth factor S homeolog Protein, NGF Protein, Ngf Protein, ngfb Protein, ngf Protein, ngf.S Protein

Background:

Abbreviation: NGF,NGFB,beta-NGF

Target Synonym: Beta-Nerve Growth Factor,Beta-NGF,NGF,NGFB

Background: NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90 % homology at the amino acid level with human beta -NGF and 95.8 % with rat beta -NGF. NGF signaling has been shown to play an important role in neuroprotection and repair. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.

Molecular Weight:

Calculated MW: 13.09 kDa

Observed MW: 15 kDa

UniProt: P01139

Pathways: Regulation of Cell Size