CD22 Protein (AA 22-341) (His tag)

Catalog No. ABIN7505446

Product Details

Target: CD22 (CD22 Molecule (CD22))

Protein Type: Recombinant

Protein Characteristics: AA 22-341

Origin: Mouse

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CD22 protein is labelled with His tag.

Sequence: Ser 22-Thr 341

Characteristics: A DNA sequence encoding the Mouse CD22/Siglec-2 protein (P35329) (Ser 22-Thr 341) was expressed with N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CD22 (CD22 Molecule (CD22))

Alternative Name: CD22 (CD22 Products)

Synonyms: A530093D23 Protein, Lyb-8 Protein, Lyb8 Protein, SIGLEC-2 Protein, SIGLEC2 Protein, siglec-2 Protein, CD22 antigen Protein, CD22 molecule Protein, Cd22 Protein, CD22 Protein

Background:

Abbreviation: CD22,Siglec-2

Target Synonym: B-cell receptor CD22,BL-CAM,B-lymphocyte cell adhesion molecule,CD22 antigenMGC130020,CD22 Molecule,CD22,sialic acid binding Ig-like lectin 2,Siglec-2,SIGLEC2FLJ22814,T-cell surface antigen Leu-14

Background: Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Human Siglec-2, also known as B-cell antigen CD22 or B-lymphocyte cell adhesion molecule (BL-CAM), is a B-cell restricted glycoprotein that is expressed in the cytoplasm of progenitor B and pre-B cells and on the surface of mature B cells. Two distinct human Siglec-2/CD22 cDNAs that arise from differential RNA processing of the same gene have been isolated. Siglec-2/CD22 is an adhesion molecule that preferentially binds alpha 2,6- linked sialic acid on the same (cis) or adjacent (trans) cells. Interaction of CD22 with trans ligands on opposing cells was found to be favored over the binding of ligands in cis.

Molecular Weight:

Calculated MW: 35.09 kDa

Observed MW: 40 kDa

UniProt: P35329