GSTP1 Protein (AA 2-210) (His tag)

Catalog No. ABIN7505432

Product Details

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Protein Type: Recombinant

Protein Characteristics: AA 2-210

Origin: Mouse

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This GSTP1 protein is labelled with His tag.

Sequence: Pro 2-Gln 210

Characteristics: A DNA sequence encoding the Mouse GSTp1 protein (P19157) (Pro 2-Gln 210) was expressed with N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Alternative Name: GSTp1 (GSTP1 Products)

Synonyms: DFN7 Protein, FAEES3 Protein, GST3 Protein, GSTP Protein, PI Protein, GST-P Protein, Gst3 Protein, Gstp Protein, Gstp2 Protein, gst-Pi Protein, GstpiB Protein, glutathione S-transferase P-like Protein, glutathione S-transferase pi 1 Protein, glutathione S-transferase pi 1 L homeolog Protein, glutathione S-transferase, pi 1 Protein, LOC100739163 Protein, GSTP1 Protein, Gstp1 Protein, LOC100861197 Protein, gstp1.L Protein

Background:

Abbreviation: GSTp1

Target Synonym: Glutathione S-transferase P,GSTP1,GST class-pi,GSTP1-1,FAEES3,GST3

Background: Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins. Besides, it regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. It thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

Molecular Weight:

Calculated MW: 22.88 kDa

Observed MW: 28 kDa

UniProt: P19157

Pathways: Cellular Response to Molecule of Bacterial Origin