Cyclin D3 Protein (CCND3) (AA 1-292) (His tag)
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- Target See all Cyclin D3 (CCND3) Proteins
- Cyclin D3 (CCND3)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-292
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Cyclin D3 protein is labelled with His tag.
- Sequence
- Met 1-Leu 292
- Characteristics
- A DNA sequence encoding the Mouse cyclin D3/CCND3 protein (P30282) (Met 1-Leu 292) was expressed with N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CCND3 Protein
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Cyclin D3 (CCND3) (AA 1-292) protein (GST tag)
CCND3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cyclin D3 (CCND3) (AA 1-100) protein (GST tag)CCND3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- Cyclin D3 (CCND3)
- Alternative Name
- cyclin D3 (CCND3 Products)
- Synonyms
- zgc:103502 Protein, CCND3 Protein, 9230106B05Rik Protein, AA682053 Protein, AL024085 Protein, AW146355 Protein, C78795 Protein, cyclin D3 Protein, ccnd3 Protein, CCND3 Protein, Ccnd3 Protein
- Background
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Abbreviation: cyclin D3,CCND3
Target Synonym: G1/S-specific cyclin-D3,CyclinD3
Background: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- Molecular Weight
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Calculated MW: 32.01 kDa
Observed MW: 35 kDa
- UniProt
- P30282
- Pathways
- Cell Division Cycle, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process
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