CD96 Protein (CD96) (AA 22-174) (His tag)

Catalog No. ABIN7505421

Product Details

Target: CD96

Protein Type: Recombinant

Protein Characteristics: AA 22-174

Origin: Mouse

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CD96 protein is labelled with His tag.

Sequence: Val 22-Phe 174

Characteristics: A DNA sequence encoding the Mouse CD96/TACTILE protein (Q3U0X8) (Val 22-Phe 174) was expressed with N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CD96

Alternative Name: CD96 (CD96 Products)

Synonyms: 1700109I12Rik Protein, Tactile Protein, TACTILE Protein, CD96 antigen Protein, CD96 molecule Protein, Cd96 Protein, CD96 Protein

Background:

Abbreviation: CD96,TACTILE

Target Synonym: T-cell surface protein tactile,Cell surface antigen CD96,T cell-activated increased late expression protein

Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. The CD155 ligand CD96 is a member of the Ig superfamily. It's a immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. NK cells recognize poliovirus receptor (PVR), a nectins and nectin-like protein family member serve to mediate cell-cell adhesion, cell migration, with the presence of an additional receptor, CD96. CD96 promotes NK cell adhesion to target cells expressing PVR, stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. The effect the cells with mutated CD96 protein lost adhesion and growth activities indicates that CD96 mutations may cause a form of the C syndrome by interfering with cell adhesion and growth.

Molecular Weight:

Calculated MW: 16.72 kDa

Observed MW: 22 kDa

UniProt: Q3U0X8