BCR Protein (AA 618-824) (His tag)

Catalog No. ABIN7505420

Product Details

Target: BCR (Breakpoint Cluster Region (BCR))

Protein Type: Recombinant

Protein Characteristics: AA 618-824

Origin: Mouse

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This BCR protein is labelled with His tag.

Sequence: Ser 618-Leu 824

Characteristics: A DNA sequence encoding the Mouse BCR protein (Q6PAJ1) (Ser 618-Leu 824) was expressed with N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: BCR (Breakpoint Cluster Region (BCR))

Alternative Name: BCR (BCR Products)

Synonyms: si:dkey-83d9.7 Protein, zK83D9.7 Protein, BCR Protein, ALL Protein, BCR1 Protein, CML Protein, D22S11 Protein, D22S662 Protein, PHL Protein, 5133400C09Rik Protein, AI561783 Protein, AI853148 Protein, mKIAA3017 Protein, breakpoint cluster region Protein, BCR, RhoGEF and GTPase activating protein Protein, bcr Protein, BCR Protein, Bcr Protein

Background:

Abbreviation: BCR

Target Synonym: ALL,Breakpoint cluster region,CML,D22S662,FGFR1/BCR chimera protein,PHLRenal carcinoma antigen NY-REN-26

Background: The Bcr gene was orginally identified by its presence in the chimeric Bcr-Abl oncogene. The amino-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain, and a region that binds SH2 domains. The middle of the protein has a PH domain and a region of sequence similarity to the guanine nucleotide exchange factors for the Rho family of GTP binding proteins. The carboxy-terminal region may be involved in a GTPase activating function for the small GTP-binding protein Rac. The function of wild type Bcr in cells remains unclear. PDGF receptor may use Bcr as a downstream signaling mediator. Research studies have shown that the Bcr-Abl fusion results in production of a constitutively active tyrosine kinase, which causes chronic myelogenous leukemia (CML). Tyr177 of Bcr is phosphorylated in the Bcr-Abl fusion protein, which plays an important role in transforming the activity of Bcr-Abl). Phosphorylated Tyr177 provides a docking site for Gab2 and GRB2.

Molecular Weight:

Calculated MW: 22.66 kDa

Observed MW: 30 kDa

UniProt: Q6PAJ1

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling