LDLR Protein (AA 263-509) (His tag)
-
- Target See all LDLR Proteins
- LDLR (Low Density Lipoprotein Receptor (LDLR))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 263-509
-
Origin
- Mouse
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This LDLR protein is labelled with His tag.
- Sequence
- Lys 263-Asp 509
- Characteristics
- A DNA sequence encoding the Mouse LDLR protein (P35951) (Lys 263-Asp 509) was expressed with a N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product LDLR Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
-
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
-
- Target
- LDLR (Low Density Lipoprotein Receptor (LDLR))
- Alternative Name
- LDLR (LDLR Products)
- Synonyms
- FH Protein, FHC Protein, LDLCQ2 Protein, Hlb301 Protein, LDLRA Protein, LDLA Protein, LDL receptor-2 Protein, fhc Protein, ldlcq2 Protein, ldlr Protein, ldlr2-a Protein, LDL receptor 1 Protein, ldlr-a Protein, ldlr-b Protein, low density lipoprotein receptor Protein, low density lipoprotein receptor a Protein, low density lipoprotein receptor S homeolog Protein, low density lipoprotein receptor L homeolog Protein, LDLR Protein, Ldlr Protein, ldlra Protein, ldlr.S Protein, ldlr.L Protein
- Background
-
Abbreviation: LDLR
Target Synonym: Hlb301,Ldlr,LDLR,Low-density lipoprotein receptor
Background: LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.
- Molecular Weight
-
Calculated MW: 27.06 kDa
Observed MW: 35 kDa
- UniProt
- P35951
- Pathways
- Hepatitis C, Lipid Metabolism
-