Caspase 1 Protein (CASP1) (AA 120-296) (His tag)
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- Target See all Caspase 1 (CASP1) Proteins
- Caspase 1 (CASP1)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 120-296
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Caspase 1 protein is labelled with His tag.
- Sequence
- Asn 120-Asp 296
- Characteristics
- A DNA sequence encoding the Mouse CASP1 protein (P29452) (Asn 120-Asp 296) was expressed with a N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CASP1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- Caspase 1 (CASP1)
- Alternative Name
- CASP1 (CASP1 Products)
- Synonyms
- ICE Protein, IL1BC Protein, P45 Protein, Il1bc Protein, Ice Protein, CASP1 Protein, CG5370 Protein, DCP-1 Protein, DCP1 Protein, Dcp1 Protein, Dmel\\CG5370 Protein, ccp1 Protein, dcp-1 Protein, dcp1 Protein, l(2)01862 Protein, l(2)02132 Protein, caspase 1 Protein, caspase 1, apoptosis-related cysteine peptidase Protein, caspase 4, apoptosis-related cysteine peptidase Protein, Death caspase-1 Protein, caspase-1 Protein, caspase Protein, caspase recruitment domain-containing protein 16 Protein, caspase 4 Protein, CASP1 Protein, Casp1 Protein, CASP4 Protein, Dcp-1 Protein, Caspase1 Protein, LOC5564196 Protein, LOC451519 Protein
- Background
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Abbreviation: CASP1
Target Synonym: CASP-1,CASP1,CASP1,Caspase 1,Caspase-1 subunit p10,ICE,IL-1 beta-converting enzyme,IL-1BC
Background: Caspase-1, also known as IL-1 beta -converting enzyme (ICE), is an aspartic protease that plays a key role in the inflammatory response and apoptosis. Caspase-1 precursor (about 50 kDa) can be cleaved and the active enzyme consists of a complex of two 20 kDa (aa 120-297) and two 10 kDa (aa 317-404) subunits which associate following cleavage of inactive precursors. Caspase-1 is required for proteolytic cleavage of the IL-1 beta precursor to form the active proinflammatory cytokine. Alternate splicing generates several additional Caspase-1 isoforms with deletions in the propeptide regions or also in the mature subunits.
- Molecular Weight
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Calculated MW: 19.36 kDa
Observed MW: 21 kDa
- UniProt
- P29452
- Pathways
- Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome
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