ACTH Protein (AA 27-235) (His tag)
-
- Target See all ACTH Proteins
- ACTH (Adrenocorticotropic hormone (ACTH))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 27-235
-
Origin
- Mouse
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This ACTH protein is labelled with His tag.
- Sequence
- Trp 27-Gln 235
- Characteristics
- A DNA sequence encoding the Mouse ACTH protein (P01193) (Trp 27-Gln 235) was expressed with a N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
-
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
-
- Target
- ACTH (Adrenocorticotropic hormone (ACTH))
- Alternative Name
- ACTH (ACTH Products)
- Synonyms
- ACTH Protein, BE Protein, Beta-LPH Protein, Clip Protein, Gamma-LPH Protein, Npp Protein, Pomc-1 Protein, Pomc1 Protein, alpha-MSH Protein, alphaMSH Protein, beta-MSH Protein, gamma-MSH Protein, CLIP Protein, LPH Protein, MSH Protein, NPP Protein, POC Protein, pro-opiomelanocortin-alpha Protein, proopiomelanocortin Protein, Pomc Protein, POMC Protein
- Background
-
Abbreviation: ACTH
Target Synonym: ACTH,Adrenocorticotropic hormone,Adrenocorticotropin,Pomc,Pomc1,POC,POMC,Pomc-1,Pomc1,Pmc2
Background: Adrenocorticotropic hormone (ACTH)/corticotropin is a 39 amino acid peptide generated by cleavage of the POMC, a preprotein which also can also be cleaved to produce MSH, Beta-endorphin and Met-enkephalin, depending on tissue expression and context. ACTH is a ligand for the ACTH receptor, also known as melanocortin receptor 2. ACTH is secreted by the anterior pituitary gland upon stimulation by corticotropin-releasing hormone (CRH) which is secreted by the hypothalamus. The principal effect of ACTH is production of cortisol by the adrenal gland but it also mediates bone formation and osteoblast survival. ACTH has been shown to induce insulin resistance in adipocytes and promote pro-inflammatory adipokine secretion.
- Molecular Weight
-
Calculated MW: 22.88 kDa
Observed MW: 30 kDa
- UniProt
- P01193
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity
-
