OPTN Protein (AA 1-353) (His tag)
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- Target See all OPTN Proteins
- OPTN (Optineurin (OPTN))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-353
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This OPTN protein is labelled with His tag.
- Sequence
- Met1-353Glu
- Characteristics
- A DNA sequence encoding the Human OPTN protein (Q96CV9) (Met1-353Glu) was expressed with a N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product OPTN Protein
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Optineurin (OPTN) (AA 16-223) protein (His-IF2DI Tag)
OPTN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Optineurin (OPTN) (AA 1-577) protein (GST tag)OPTN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Optineurin (OPTN) (AA 1-571) protein (GST tag)OPTN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Optineurin (OPTN) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)OPTN Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- OPTN (Optineurin (OPTN))
- Alternative Name
- OPTN (OPTN Products)
- Synonyms
- nrp Protein, fip2 Protein, hip7 Protein, hypl Protein, glc1e Protein, tfiiia-intp Protein, ALS12 Protein, FIP2 Protein, GLC1E Protein, HIP7 Protein, HYPL Protein, NRP Protein, TFIIIA-INTP Protein, Fip2 Protein, 4930441O07Rik Protein, fj52f04 Protein, si:ch211-240l19.3 Protein, wu:fj52f04 Protein, zgc:66386 Protein, zgc:77868 Protein, optineurin Protein, optineurin L homeolog Protein, OPTN Protein, optn Protein, Optn Protein, optn.L Protein
- Background
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Abbreviation: OPTN
Target Synonym: Optineurin,OPTN,
Background: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.
- Molecular Weight
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Calculated MW: 38.72 kDa
Observed MW: 45 kDa
- UniProt
- Q96CV9
- Pathways
- M Phase
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