Adenylate Kinase 2 Protein (AK2) (AA 1-239) (GST-His-Tag)

Catalog No. ABIN7505329

Product Details

Target: Adenylate Kinase 2 (AK2)

Protein Type: Recombinant

Protein Characteristics: AA 1-239

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Adenylate Kinase 2 protein is labelled with GST-His-Tag.

Sequence: Met 1-Ile 239

Characteristics: A DNA sequence encoding the Human AK2/Adenylate kinase 2 Protein (P54819) (Met 1-Ile 239) was expressed with a N-GST&C-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Adenylate Kinase 2 (AK2)

Alternative Name: AK2 (AK2 Products)

Synonyms: ADK-2 Protein, BcDNA:SD09634 Protein, CG3140 Protein, Dak2 Protein, Dmel\\CG3140 Protein, anon-Dak2 Protein, adk2 Protein, NV10896 Protein, wu:fb34f05 Protein, wu:fj80e03 Protein, ADK2 Protein, AK 2 Protein, Ak-2 Protein, D4Ertd220e Protein, MXI22.8 Protein, MXI22_8 Protein, Adenylate kinase 2 Protein, adenylate kinase 2 Protein, adenylate kinase Protein, adenylate kinase 2 S homeolog Protein, Adenylate kinase family protein Protein, Adk2 Protein, AK2 Protein, ak2 Protein, LOC100123971 Protein, ak2.S Protein, Ak2 Protein, AT5G50370 Protein

Background:

Abbreviation: AK2;Adenylate kinase 2

Target Synonym: ADK2;AK2

Background: Adenylate kinase 2 (AK2) belongs to the Adenylate kinase family that contains three isozymes: AK1, AK2 and AK3. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Adenylate kinase2 (AK2) is expressed in mitochondrial intermembrane space. It may play a role in apoptosis. It has been demonstrated that in apoptotic cells AK2 was translocated into the cytosol concomitantly with cytochronme C. Mutations in this gene are the cause of reticular dysgenesis. These mutations result in absent or strongly decreased protein expression. It has been also established that AK2 is specifically expressed in the stria vascularis region of the inner ear, which provides an explanation of the sensorineural deafness in these individuals. 

Molecular Weight:

Calculated MW: 51.18 kDa

Observed MW: 52 kDa

UniProt: P54819

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process