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CD69 Protein (CD69) (AA 63-199) (GST-His-Tag)

CD69 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7505323
  • Target See all CD69 Proteins
    CD69
    Protein Type
    Recombinant
    Protein Characteristics
    AA 63-199
    Origin
    • 11
    • 4
    • 3
    • 1
    Human
    Source
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This CD69 protein is labelled with GST-His-Tag.
    Sequence
    Val 63-Lys 199
    Characteristics
    A DNA sequence encoding the Human CLEC2C/CD69 protein (Q07108) (Val 63-Lys 199) was expressed with a N-GST&C-His tag.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product CD69 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Expiry Date
    12 months
  • Target
    CD69
    Alternative Name
    CLEC2C (CD69 Products)
    Synonyms
    5830438K24Rik Protein, AI452015 Protein, AIM Protein, VEA Protein, BL-AC/P26 Protein, CLEC2C Protein, EA1 Protein, GP32/28 Protein, MLR-3 Protein, Cd69 molecule Protein, CD69 antigen Protein, CD69 molecule Protein, Cd69 Protein, CD69 Protein
    Background

    Abbreviation: CLEC2C,CD69

    Target Synonym: arly activation antigen CD69,Activation inducer molecule,AIM,BL-AC/P26,C-type lectin domain family 2 member C,EA1,Early T-cell activation antigen p60,GP32/28,Leukocyte surface antigen Leu-23,MLR-3,CD69,CLEC2C

    Background: Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.

    Molecular Weight

    Calculated MW: 39.96 kDa

    Observed MW: 40 kDa

    UniProt
    Q07108
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