CD69 Protein (CD69) (AA 63-199) (GST-His-Tag)
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- Target See all CD69 Proteins
- CD69
- Protein Type
- Recombinant
- Protein Characteristics
- AA 63-199
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CD69 protein is labelled with GST-His-Tag.
- Sequence
- Val 63-Lys 199
- Characteristics
- A DNA sequence encoding the Human CLEC2C/CD69 protein (Q07108) (Val 63-Lys 199) was expressed with a N-GST&C-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CD69 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- CD69
- Alternative Name
- CLEC2C (CD69 Products)
- Synonyms
- 5830438K24Rik Protein, AI452015 Protein, AIM Protein, VEA Protein, BL-AC/P26 Protein, CLEC2C Protein, EA1 Protein, GP32/28 Protein, MLR-3 Protein, Cd69 molecule Protein, CD69 antigen Protein, CD69 molecule Protein, Cd69 Protein, CD69 Protein
- Background
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Abbreviation: CLEC2C,CD69
Target Synonym: arly activation antigen CD69,Activation inducer molecule,AIM,BL-AC/P26,C-type lectin domain family 2 member C,EA1,Early T-cell activation antigen p60,GP32/28,Leukocyte surface antigen Leu-23,MLR-3,CD69,CLEC2C
Background: Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.
- Molecular Weight
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Calculated MW: 39.96 kDa
Observed MW: 40 kDa
- UniProt
- Q07108
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