COMP Protein (AA 22-240) (GST-His-Tag)
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- Target See all COMP Proteins
- COMP (Cartilage Oligomeric Matrix Protein (COMP))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-240
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This COMP protein is labelled with GST-His-Tag.
- Sequence
- Gly 22-His 240
- Characteristics
- A DNA sequence encoding the Human COMP protein (P49747) (Gly 22-His 240) was expressed with a N-GST&C-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product COMP Protein
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Cartilage Oligomeric Matrix Protein (COMP) (C-Term) protein
COMP Origin: Rat Recombinant > 95 % (SDS-PAGE)
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- COMP (Cartilage Oligomeric Matrix Protein (COMP))
- Alternative Name
- COMP (COMP Products)
- Synonyms
- COMP Protein, EDM1 Protein, EPD1 Protein, MED Protein, PSACH Protein, THBS5 Protein, TSP5 Protein, cartilage oligomeric matrix protein Protein, COMP Protein, sce3551 Protein, CJA_1292 Protein, Comp Protein
- Background
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Abbreviation: COMP
Target Synonym: EDM1,EPD1,MED,PSACH,THBS5
Background: Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and function. It is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas.
- Molecular Weight
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Calculated MW: 48.98 kDa
Observed MW: 50 kDa
- UniProt
- P49747
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