Fatty Acid Synthase Protein (FASN) (AA 2201-2511) (His tag)

Catalog No. ABIN7505310

Product Details

Target: Fatty Acid Synthase (FASN)

Protein Type: Recombinant

Protein Characteristics: AA 2201-2511

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Fatty Acid Synthase protein is labelled with His tag.

Sequence: Ala 2201-Gly 2511

Characteristics: A DNA sequence encoding the Human FattyAcidSynthase protein (P49327) (Ala 2201-Gly 2511) was expressed with a C-His.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Fatty Acid Synthase (FASN)

Alternative Name: FattyAcidSynthase (FASN Products)

Synonyms: FAS Protein, OA-519 Protein, SDR27X1 Protein, FASN Protein, fj34h12 Protein, wu:fj34h12 Protein, Cgl0836 Protein, A630082H08Rik Protein, BcDNA:GH07626 Protein, BcDNA:gh07626 Protein, DM_7295848 Protein, Dmel\\CG3523 Protein, Fatty acid synthase Protein, anon-EST:Posey235 Protein, anon-EST:Posey43 Protein, anon-WO0138581.1 Protein, dFAS Protein, fas Protein, fatty acid synthase Protein, fatty acid synthase Fas Protein, type I polyketide synthase Protein, Fatty acid synthase Fas Protein, Fatty Acid SyNthase Protein, fatty-acid synthase Protein, fatty-acid synthase II Protein, fatty-acid synthase fas Protein, Fatty acid synthase 1 Protein, FASN Protein, fas Protein, Fasn Protein, BAD_RS01360 Protein, fasn Protein, fasn-1 Protein, NCgl0802 Protein, fasB Protein, MT2600 Protein, TBMG_01448 Protein, FASN1 Protein

Background:

Abbreviation: FattyAcidSynthase

Target Synonym: Fatty acid synthase,FASN,Type I fatty acid synthase,

Background: FASN (Fatty Acid Synthase, also FAS) is a cytosolic 270-280 kDa member of the short chain dehydrogenase/reductase family 27X. It is expressed in neurons, skeletal muscle, adipocytes and hepatocytes, and both catalyzes the formation of palmitic acid from acetylCoA and malonylCoA, and likely mediates the transfer of fatty acids to peptides. Human FASN is 2511 amino acids (aa) in length ands contains multiple domains, including a beta -ketoacyl synthase domain (aa 1-414), an acyl and malonyl transferase domain (aa 429-817), an enoyl reductase domain (aa 1563-1863), a beta -ketoacyl reductase domain (aa 1864-2118) and a thioesterase domain (aa 2207?2511). FASN exists as an antiparallel homodimer. There is one theoretical alternative start site at Met2073. Over aa 9-212, human FASN shares 92 % aa identity with mouse FASN.

Molecular Weight:

Calculated MW: 34.1 kDa

Observed MW: 35 kDa

UniProt: P49327

Pathways: AMPK Signaling