MAPK13 Protein (AA 51-365) (His tag)

Catalog No. ABIN7505299

Product Details

Target: MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))

Protein Type: Recombinant

Protein Characteristics: AA 51-365

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This MAPK13 protein is labelled with His tag.

Sequence: Val 51-Leu 365

Characteristics: A DNA sequence encoding the Human MAPK13 protein (O15264) (Val 51-Leu 365) was expressed with a N-His&C-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))

Alternative Name: MAPK13 (MAPK13 Products)

Synonyms: F24B9.3 Protein, F24B9_3 Protein, MAPK 13 Protein, MAPK-13 Protein, PRKM13 Protein, SAPK4 Protein, p38delta Protein, Serk4 Protein, Prkm13 Protein, sapk4 Protein, prkm13 Protein, Protein kinase superfamily protein Protein, mitogen-activated protein kinase 13 Protein, mitogen activated protein kinase 13 Protein, ATMPK13 Protein, MAPK13 Protein, Mapk13 Protein, mapk13 Protein

Background:

Abbreviation: MAPK13

Target Synonym: MAPK-13,MAPK13,p38delta,PRKM13,SAPK4

Background: The p38 family of mitogen-activated protein kinases (MAPK) includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. p38 delta, also known as MAPK13, is a regulator of differentiation-dependent gene expression in keratinocytes, and been as a regulator of surface epithelia differentiation and apoptosis. p38 delta protein is upregulated in Cholangiocarcinoma (CC) relative to hepatocellularcarcinoma (HCC) and to normal biliary tract tissues. p38 delta is important for motility and invasion of CC cells, suggesting that p38 delta may play an important role in CC metastasis. p38 delta is expressed in the epidermis, suggesting a role for p38 delta in regulating differentiation. p38 delta is the major p38 isoform driving suprabasal involucrin gene expression and that p38 delta directly regulates ERK1/2 activity via formation of a p38 delta-ERK1/2 complex. Recent emerging evidence suggests that the p38 stress MAPK pathway may function as a tumor suppressor through regulating Ras-dependent and -independent proliferation, transformation, invasion and cell death by isoform-specific mechanisms. p38 delta has important role in promoting cell proliferation and tumor development in epidermis and may have therapeutic implication for skin cancer.

Molecular Weight:

Calculated MW: 34.54 kDa

Observed MW: 41 kDa

UniProt: O15264

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Hepatitis C, BCR Signaling, S100 Proteins