ABCB1 Protein (AA 392-628) (His tag)
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- Target See all ABCB1 Proteins
- ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 392-628
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This ABCB1 protein is labelled with His tag.
- Sequence
- Leu 392-Met 628
- Characteristics
- A DNA sequence encoding the Human P-glycoprotein1(ABCB1) protein (P08183) (Leu 392-Met 628) was expressed with a N-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product ABCB1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
- Abstract
- ABCB1 Products
- Synonyms
- ABC20 Protein, CD243 Protein, CLCS Protein, GP170 Protein, MDR1 Protein, P-GP Protein, PGY1 Protein, Abcb1 Protein, Mdr1a Protein, p-gp Protein, xemdr Protein, Mdr1 Protein, Mdr1b Protein, Pgy-1 Protein, Pgy1 Protein, mdr Protein, ABCB1 Protein, PGP1 Protein, ATP binding cassette subfamily B member 1 Protein, ATP binding cassette subfamily B member 1A Protein, ATP binding cassette subfamily B member 1 L homeolog Protein, ATP-binding cassette, sub-family B (MDR/TAP), member 1B Protein, ABCB1 Protein, Abcb1a Protein, abcb1.L Protein, Abcb1b Protein, Abcb1 Protein
- Background
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Abbreviation: P-glycoprotein1,ABCB1
Target Synonym: ATP-dependent translocase ABCB1,ABCB1,ATP-binding cassette sub-family B member 1,P-glycoprotein 1,Phospholipid transporter ABCB1,CD243,
Background: Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218, PubMed:35970996). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218, PubMed:35970996).
- Molecular Weight
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Calculated MW: 25.96 kDa
Observed MW: 32 kDa
- UniProt
- P08183
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