RAB5 Protein (AA 1-215) (His tag)
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- Target See all RAB5 (RAB5A) Proteins
- RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-215
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This RAB5 protein is labelled with His tag.
- Sequence
- Met 1-Asn 215
- Characteristics
- A DNA sequence encoding the Human RAB5A protein (P20339) (Met 1-Asn 215) was expressed with a N-His&C-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product RAB5A Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))
- Alternative Name
- RAB5A (RAB5A Products)
- Synonyms
- RAB5 Protein, 2410015H04Rik Protein, AI663973 Protein, AU021172 Protein, nnyRab5a Protein, DDBDRAFT_0168594 Protein, DDBDRAFT_0229401 Protein, DDB_0168594 Protein, DDB_0229401 Protein, rab5 Protein, RAB5A Protein, Rab5a Protein, rab5al Protein, zgc:56644 Protein, fj38g08 Protein, hm:zehn1144 Protein, rab5a Protein, wu:fj38g08 Protein, RAB5A, member RAS oncogene family Protein, rab5A protein Protein, Rab5a, GTPase Protein, predicted protein Protein, Rab GTPase Protein, RAB5A, member RAS oncogene family L homeolog Protein, RAB5A, member RAS oncogene family, b Protein, RAB5A, member RAS oncogene family, a Protein, RAB5A Protein, Rab5a Protein, rab5A Protein, rab5a Protein, rab5a.L Protein, rab5ab Protein, rab5aa Protein
- Background
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Abbreviation: RAB5A
Target Synonym: Ras-related protein Rab-5A,RAB5A
Background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
- Molecular Weight
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Calculated MW: 23.54 kDa
Observed MW: 32 kDa
- UniProt
- P20339
- Pathways
- Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity
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