RUNX3 Protein (AA 1-415) (His tag)
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- Target See all RUNX3 Proteins
- RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-415
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This RUNX3 protein is labelled with His tag.
- Sequence
- Met 1-Tyr 415
- Characteristics
- A DNA sequence encoding the Human RUNX3 protein (Q13761) (Met 1-Tyr 415) was expressed with a N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product RUNX3 Protein
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Runt-Related Transcription Factor 3 (RUNX3) (AA 1-415) protein (His tag)
custom-made RUNX3 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Runt-Related Transcription Factor 3 (RUNX3) (AA 53-186) protein (His tag)RUNX3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Runt-Related Transcription Factor 3 (RUNX3) (AA 1-409) protein (His tag)custom-made RUNX3 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))
- Alternative Name
- RUNX3 (RUNX3 Products)
- Background
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Abbreviation: RUNX3
Target Synonym: Runt-related transcription factor 3,RUNX3,Acute myeloid leukemia 2 protein,Core-binding factor subunit alpha-3,Oncogene AML-2,
Background: RUNX3, also called CBFA3, AML-2 or PEBP2-alpha C, is a member of the Runt domain family of nuclear transcriptional regulators. All of the RUNX proteins form dimers with CBF-beta. The runt domain (aa 54-186) is required for DNA binding, while a pro/ser/thr-rich region (aa 191-415) transcriptionally activates target genes. Isoform 2 has an alternate 19 aa in place of the N-terminal 5 aa of isoform 1. The 415 aa Human RUNX3 shares 91 % aa identity with mouse or rat RUNX3. RUNX3 is necessary for growth control of gastric epithelium, neurogenesis of dorsal root ganglia, and T cell differentiation. RUNX3 expression is frequently mutated in tumors and appears to be silenced by methylation.
- Molecular Weight
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Calculated MW: 45.54 kDa
Observed MW: 50 kDa
- UniProt
- Q13761
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