SCO2 Protein (AA 42-266) (His tag)
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- Target See all SCO2 Proteins
- SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 42-266
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This SCO2 protein is labelled with His tag.
- Sequence
- Gly 42-Ser 266
- Characteristics
- A DNA sequence encoding the Human SCO2 protein (O43819) (Gly 42-Ser 266) was expressed with aN-His&C-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product SCO2 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))
- Alternative Name
- SCO2 (SCO2 Products)
- Synonyms
- CEMCOX1 Protein, MYP6 Protein, SCO1L Protein, SCO cytochrome oxidase deficient homolog 2 (yeast) Protein, SCO2 cytochrome c oxidase assembly protein Protein, SCO2, cytochrome c oxidase assembly protein Protein, SCO2 Protein, Sco2 Protein
- Background
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Abbreviation: SCO2
Target Synonym: Protein SCO2 homolog,mitochondrial,SCO2,
Background: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) . This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.
- Molecular Weight
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Calculated MW: 24.64 kDa
Observed MW: 30 kDa
- UniProt
- O43819
- Pathways
- Transition Metal Ion Homeostasis, Warburg Effect
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