CREB3L4 Protein (AA 14-295) (His tag)

Catalog No. ABIN7505217

Product Details

Target: CREB3L4 (cAMP Responsive Element Binding Protein 3-Like 4 (CREB3L4))

Protein Type: Recombinant

Protein Characteristics: AA 14-295

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CREB3L4 protein is labelled with His tag.

Sequence: Glu 14-Ser 295

Characteristics: A DNA sequence encoding the Human CREB3L4 protein (Q8TEY5) (Glu 14-Ser 295) was expressed with a C-His and N-His.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CREB3L4 (cAMP Responsive Element Binding Protein 3-Like 4 (CREB3L4))

Alternative Name: CREB3L4 (CREB3L4 Products)

Synonyms: CREB3L4 Protein, aibzip Protein, atce1 Protein, creb3 Protein, creb4 Protein, hjal Protein, jal Protein, tisp40 Protein, AIBZIP Protein, ATCE1 Protein, CREB3 Protein, CREB4 Protein, JAL Protein, hJAL Protein, 1700012K17Rik Protein, 5330432F22Rik Protein, AV040530 Protein, AV258827 Protein, Atce1 Protein, TISP40 Protein, Tisp40alpha Protein, Tisp40beta Protein, mJAL Protein, AIbZIP Protein, cAMP responsive element binding protein 3 like 4 Protein, cAMP responsive element binding protein 3-like 4 Protein, CREB3L4 Protein, creb3l4 Protein, Creb3l4 Protein

Background:

Abbreviation: CREB3L4

Target Synonym: Cyclic AMP-responsive element-binding protein 3-like protein 4,CREB3L4,cAMP-responsive element-binding protein 3-like protein 4,Androgen-induced basic leucine zipper protein (AIbZIP),Attaching to CRE-like 1 (ATCE1),Cyclic AMP-responsive element-binding pr

Background: The cyclic AMP responsive element-binding protein 3-like 4 (CREB3L4) is a transcription factor highly expressed in multiple human cancers. This study aimed to investigate the regulatory effects of CREB3L4 on GC progression and angiogenesis. CREB3L4 was overexpressed in GC tissues and cell lines, and was positively correlated with advanced tumor stage and poor survival in GC patients. The upregulation of CREB3L4 in GC cells increased cell viability, promoted cell proliferation, reduced apoptosis, enhanced cell migration and invasion, and induced the formation of tubule-like endothelial structures, whereas CREB3L4 knockdown impeded tumor cell growth, attenuated cell motility, and prevented human umbilical vein endothelial cells from forming tubule-like structures. In addition, mice inoculated with CREB3L4-deficient GC cells showed significantly suppressed tumor growth compared to the group harboring wild-type tumors.

Molecular Weight:

Calculated MW: 32.186 kDa

Observed MW: 40 kDa

UniProt: Q8TEY5

Pathways: Thyroid Hormone Synthesis