RAB5B Protein (AA 1-215) (His tag)
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- Target See all RAB5B Proteins
- RAB5B (RAB5B, Member RAS Oncogene Family (RAB5B))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-215
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This RAB5B protein is labelled with His tag.
- Sequence
- Met 1-Asn 215
- Characteristics
- A DNA sequence encoding the Human RAB5B protein (P61020) (Met 1-Asn 215) was expressed with a C-His,N-His.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product RAB5B Protein
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RAB5B, Member RAS Oncogene Family (RAB5B) (AA 1-215) protein (GST tag)
RAB5B Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
RAB5B, Member RAS Oncogene Family (RAB5B) (AA 116-215) protein (GST tag)RAB5B Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- RAB5B (RAB5B, Member RAS Oncogene Family (RAB5B))
- Alternative Name
- RAB5B (RAB5B Products)
- Synonyms
- zgc:76978 Protein, C030027M18Rik Protein, RAB5B, member RAS oncogene family Protein, RAB5B, member RAS oncogene family L homeolog Protein, rab5b Protein, LOC613071 Protein, RAB5B Protein, Rab5b Protein, rab5b.L Protein
- Background
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Abbreviation: RAB5B
Target Synonym: Ras-related protein Rab-5B,RAB5B
Background: Antisense inhibition of Rab5b, a gene coding for a small GTPase associated with endocytosis, significantly reduced the mGluR-mediated neuroprotection. Ras-related protein Rab-5B (RAB5B), which is identified by a genome-wide association study as a risk locus for this syndrome, encodes a small GTPase involved in the control of receptor internalization and early endosome fusion. Previous genome-wide sequencing revealed that RAB5B is a susceptible target in patients with polycystic ovary syndrome (PCOS). RAB5A gene was abnormally expressed in luteinized granulosa cells of obese patients with polycystic ovary syndrome, which may help explain high FSHR levels found in this syndrome. RAB5B is directly downregulated by miR-130a-3p. Knockdown of RAB5B also inhibited cell proliferation, migration, and invasion.
- Molecular Weight
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Calculated MW: 23.54 kDa
Observed MW: 30 kDa
- UniProt
- P61020-1
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