HDAC1 Protein (AA 9-321) (His tag)

Catalog No. ABIN7505153

Product Details

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Protein Type: Recombinant

Protein Characteristics: AA 9-321

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This HDAC1 protein is labelled with His tag.

Sequence: Arg 9-Asp 321

Characteristics: A DNA sequence encoding the Human HDAC1 protein (Q13547) (Arg 9-Asp 321) was expressed with a N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Alternative Name: HDAC1 (HDAC1 Products)

Synonyms: GON-10 Protein, HD1 Protein, RPD3 Protein, RPD3L1 Protein, CG7471 Protein, DHDAC1 Protein, DRpd3 Protein, DmHDAC1 Protein, Dmel\\CG7471 Protein, E(var)3-64BC Protein, HDAC Protein, HDAC-1 Protein, HDAC1 Protein, Hdac1 Protein, Rpd3/HDAC Protein, Su(var)3-26 Protein, Su(var)326 Protein, Su(var)328 Protein, dHDAC-1 Protein, dHDAC1 Protein, dRPD3 Protein, dRpd3 Protein, dmHDA401 Protein, drpd3 Protein, hdac1 Protein, l(3)04556 Protein, l(3)64Cc Protein, rpd3 Protein, rpd[3] Protein, gon-10 Protein, hdac1b Protein, rpd3l1 Protein, Rpd3 Protein, GB14706 Protein, hdac1-b Protein, chunp6919 Protein, hdac-1 Protein, mp:zf637-2-001987 Protein, wu:fb19h11 Protein, wu:fi06f03 Protein, zgc:101582 Protein, zgc:65818 Protein, Hdac1-ps Protein, MommeD5 Protein, ARABIDOPSIS HISTONE DEACETYLASE 1 Protein, ARABIDOPSIS HISTONE DEACETYLASE 19 Protein, ATHD1 Protein, ATHDA19 Protein, ATRPD3A Protein, F20D10.250 Protein, F20D10_250 Protein, HDA1 Protein, HDA19 Protein, HISTONE DEACETYLASE Protein, HISTONE DEACETYLASE 19 Protein, HISTONE DEACETYLASE19 Protein, RPD3A Protein, histone deacetylase 1 Protein, HDM Protein, ab21 Protein, hdac1a Protein, histone deacetylase 1 Protein, Histone deacetylase 1 Protein, histone deacetylase Protein, histone deacetylase 1 S homeolog Protein, histone deacetylase Rpd3 Protein, histone deacetylase 1 L homeolog Protein, HDAC1 Protein, hdac1.S Protein, LOC411503 Protein, hdac1 Protein, Hdac1 Protein, HD1 Protein, hda-1 Protein, hdac1.L Protein, LOC748850 Protein

Background:

Abbreviation: HDAC1

Target Synonym: GON 10,HD1,HDAC 1,Histone deacetylase 1,RPD3L1

Background: Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription. HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes. In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity. Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases. Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents.

Molecular Weight:

Calculated MW: 34.32 kDa

Observed MW: 35 kDa

UniProt: Q13547

Pathways: Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis