MAP1LC3A Protein (AA 1-125) (His tag)
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- Target See all MAP1LC3A Proteins
- MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-125
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MAP1LC3A protein is labelled with His tag.
- Sequence
- Met 1-Val 125
- Characteristics
- A DNA sequence encoding the Human LC3A/B protein (Q9GZQ8) (Met 1-Val 125) was expressed with a N-10His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product MAP1LC3A Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A))
- Alternative Name
- LC3A (MAP1LC3A Products)
- Synonyms
- ATG8E Protein, LC3 Protein, LC3A Protein, MAP1ALC3 Protein, MAP1BLC3 Protein, 1010001H21Rik Protein, 4922501H04Rik Protein, LC3a Protein, MGC69006 Protein, zgc:77094 Protein, MGC89867 Protein, MAP1LC3A Protein, map1lc3a Protein, microtubule associated protein 1 light chain 3 alpha Protein, microtubule-associated protein 1 light chain 3 alpha Protein, microtubule associated protein 1 light chain 3 alpha S homeolog Protein, MAP1LC3A Protein, Map1lc3a Protein, map1lc3a.S Protein, map1lc3a Protein
- Background
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Abbreviation: MLP3B,MAP1LC3B
Target Synonym: MLP3B,ATG8F,Autophagy related protein LC3 A,Autophagy related ubiquitin like modifier LC3 A,Autophagy related ubiquitin like modifier LC3 B,LC3,MAP1 light chain 3 like protein 1,MAP1 light chain 3 like protein 2,MAP1A/1B light chain 3 A,MAP1A/1BLC3,MAP1ALC3,MAP
Background: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
- Molecular Weight
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Calculated MW: 13.64 kDa
Observed MW: 18 kDa
- UniProt
- Q9GZQ8
- Pathways
- Autophagy
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