SNCA Protein (AA 1-140) (His tag)
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- Target See all SNCA Proteins
- SNCA (Synuclein, alpha (SNCA))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-140
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This SNCA protein is labelled with His tag.
- Sequence
- Met 1-Ala 140
- Characteristics
- A DNA sequence encoding the Human Synuclein-α(SNCA) protein (P37840) (Met 1-Ala 140) was expressed with a N-His&C-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product SNCA Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- SNCA (Synuclein, alpha (SNCA))
- Alternative Name
- Synuclein-alpha (SNCA Products)
- Synonyms
- snca Protein, MGC64356 Protein, LOC619283 Protein, NACP Protein, alphaSYN Protein, PARK1 Protein, PARK4 Protein, PD1 Protein, synuclein alpha L homeolog Protein, alpha-synuclein Protein, synuclein alpha Protein, synuclein, alpha Protein, snca.L Protein, LOC619283 Protein, SNCA Protein, Snca Protein
- Background
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Abbreviation: Synuclein-α
Target Synonym: Vascular endothelial growth factor receptor 2,KDR,VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase insert domain receptor,Protein-tyrosine kinase receptor flk-1,CD309,Flk-1,FLK1,VEGFR,VEGFR2
Background: Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). In addition, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease.
- Molecular Weight
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Calculated MW: 15.29 kDa
Observed MW: 19 kDa
- UniProt
- P37840
- Pathways
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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