IL-22 Protein (AA 29-109) (His-Avi Tag)
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- Target See all IL-22 (IL22) Proteins
- IL-22 (IL22) (Interleukin 22 (IL22))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 29-109
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This IL-22 protein is labelled with His-Avi Tag.
- Sequence
- Gln 29-Asp 109
- Characteristics
- A DNA sequence encoding the Human IL22 N terminal protein (Q9GZX6) (Gln 29-Asp 109) was expressed with a C-Avi-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product IL22 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- IL-22 (IL22) (Interleukin 22 (IL22))
- Alternative Name
- IL22 (IL22 Products)
- Synonyms
- IL-21 Protein, IL-22 Protein, IL-D110 Protein, IL-TIF Protein, ILTIF Protein, TIFIL-23 Protein, TIFa Protein, zcyto18 Protein, IL-22a Protein, ILTIFa Protein, Iltif Protein, RGD1561292 Protein, interleukin-22 Protein, interleukin 22 Protein, IL22 Protein, il22 Protein, Il22 Protein
- Background
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Abbreviation: IL22 N terminal
Target Synonym: Interleukin-22,IL-22,Cytokine Zcyto18,IL-10-related T-cell-derived-inducible factor,IL-TIF,IL22,IL-D110,IL-TIF,ILTIF,TIFa,TIFIL-23,zcyto18
Background: Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
- Molecular Weight
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Calculated MW: 8.8 kDa
Observed MW: 15 kDa
- UniProt
- Q9GZX6
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