PODXL Protein (AA 220-431) (SUMO Tag,His tag)

Catalog No. ABIN7505116

Product Details

Target: PODXL (Podocalyxin-Like (PODXL))

Protein Type: Recombinant

Protein Characteristics: AA 220-431

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This PODXL protein is labelled with SUMO Tag,His tag.

Sequence: Ala 220-Ile 431

Characteristics: A DNA sequence encoding the Human PODXL protein (O00592) (Ala 220-Ile 431) was expressed with a N-SUMO-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: PODXL (Podocalyxin-Like (PODXL))

Alternative Name: PODXL (PODXL Products)

Synonyms: Gp200 Protein, PC Protein, PCLP Protein, PCLP-1 Protein, PCB Protein, AW121214 Protein, Ly102 Protein, Pclp1 Protein, podocalyxin Protein, MEP21 Protein, PODXL Protein, Gp135 Protein, PCLP1 Protein, cPCLP1 Protein, podxl Protein, fc18d02 Protein, wu:fc18d02 Protein, Pc Protein, Pcb Protein, Podxl Protein, podocalyxin like Protein, pyruvate carboxylase Protein, podocalyxin-like Protein, PODXL Protein, PC Protein, Podxl Protein, podxl Protein, Pcx Protein

Background:

Abbreviation: PODXL

Target Synonym: PCLP,PCLP1,PCLP-1,PCLPGCTM-2 antigen,PCpodocalyxin,POD XL,Podocalyxin,Podocalyxin-like protein 1,podocalyxin-like,PODXL

Background: Podocalyxin (PODXL), also known as Podocalyxin-like protein 1 (PCLP-1), is a heavily glycosylated transmembrane sialoprotein in the CD34 and Endoglycan family.Podocalyxin is expressed on glomerular and vascular endothelial cells, neurons, hematopoietic, mesenchymal, and cardiac stem cells, and metastatic carcinoma and glioblastoma tumor cells. A soluble form of Podocalyxin can be released into the urine of women with pre-eclampsia. Podocalyxin promotes platelet activation, neurite outgrowth, branching, and synaptogenesis, homing of hematopoietic progenitor cells to the bone marrow and spleen, and engraftment of mesenchymal and cardiac stem cells into ischemic heart and kidney. Its interactions with L-Selectin and E-Selectin mediate the tethering of lymphocytes and metastatic tumor cells to the vascular endothelium.

Molecular Weight:

Calculated MW: 34.21 kDa

Observed MW: 32 kDa

UniProt: O00592

Pathways: Tube Formation