MSMB Protein (His tag)

Catalog No. ABIN7505115

Product Details

Target: MSMB (Microseminoprotein, beta (MSMB))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This MSMB protein is labelled with His tag.

Sequence: P05111(Ser 233-Ile 366)-GGGGS*3-P09529(Gly 293-Ala 407)

Characteristics: A DNA sequence encoding the Human INHB protein (P05111/P09529) (P05111(Ser 233-Ile 366)-GGGGS*3-P09529(Gly 293-Ala 407)) was expressed with a N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: MSMB (Microseminoprotein, beta (MSMB))

Alternative Name: INHB (MSMB Products)

Synonyms: HPC13 Protein, IGBF Protein, MSP Protein, MSPB Protein, PN44 Protein, PRPS Protein, PSP Protein, PSP-94 Protein, PSP57 Protein, PSP94 Protein, MSMB Protein, PIP Protein, beta-MSP Protein, microseminoprotein beta Protein, microseminoprotein, beta Protein, beta-microseminoprotein Protein, microseminoprotein, beta- Protein, MSMB Protein, Msmb Protein

Background:

Abbreviation: INHB

Target Synonym: Activin beta-B chain,INHB,INHBB,INHA

Background: Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two ? subunits, ?A ?A (activin A), ?B ?B (activin B), or ?A ?B (activin AB). Inhibin is composed of an alpha and one of two ? subunits, ?A (inhibin A) or ?B (inhibin B). Activins are produced in many cell types and organs, such as gonads, pituitary gland, and placenta. In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male, activin enhances spermatogenesis. Also, Activin plays a role in wound repair and skin morphogenesis. Activin is strongly expressed in wounded skin, and overexpression of activin in the epidermis of transgenic mice improves wound healing and enhances scar formation. Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and kidney. There is also evidence showed that lack of activin during development results in neural developmental defects.

Molecular Weight:

Calculated MW: 27.17 kDa

Observed MW: 31 kDa

UniProt: P05111, P09529