FLNC Protein (AA 2519-2725) (His tag)
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- Target See all FLNC Proteins
- FLNC (Filamin C, gamma (FLNC))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2519-2725
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This FLNC protein is labelled with His tag.
- Sequence
- Thr 2519-Pro 2725
- Characteristics
- A DNA sequence encoding the Human FLNC protein (Q14315) (Thr 2519-Pro 2725) was expressed with a N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product FLNC Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- FLNC (Filamin C, gamma (FLNC))
- Alternative Name
- FLNC (FLNC Products)
- Synonyms
- 1110055E19Rik Protein, ABP-280 Protein, ABPL Protein, Fln2 Protein, ABP280A Protein, ABPA Protein, FLN2 Protein, MFM5 Protein, MPD4 Protein, filamin C Protein, filamin C L homeolog Protein, filamin C, gamma Protein, FLNC Protein, flnc.L Protein, flnc Protein, Flnc Protein
- Background
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Abbreviation: FLNC
Target Synonym: Filamin C ,FIlamin 2,Filamin C,FLN2,FLNC,ABPL,FLN2
Background: FLNC is a muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z-disks in muscle cells. Defects in FLNC are the cause of autosomal dominant filaminopathy. Myofibrillar myopathy (MFM) is a neuromuscular disorder, usually with an adult onset, characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations. Autosomal dominant filaminopathy is a form of MFM characterized by morphological features of MFM and clinical features of a limb-girdle myopathy. A heterozygous nonsense mutation which segregates with the disease, has been identified in the FLNC gene.
- Molecular Weight
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Calculated MW: 22.66 kDa
Observed MW: 28 kDa
- UniProt
- Q14315
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