MMP2 Protein (AA 445-660) (His tag)

Catalog No. ABIN7505098

Product Details

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Protein Type: Recombinant

Protein Characteristics: AA 445-660

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This MMP2 protein is labelled with His tag.

Sequence: Tyr 445-Cys 660

Characteristics: A DNA sequence encoding the Human MMP-2 protein (P08253) (Tyr 445-Cys 660) was expressed with a N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: MMP-2 (MMP2 Products)

Synonyms: 2-MMP Protein, CG1794 Protein, DM2-MMP Protein, Dm2-MMP Protein, Dmel\\CG1794 Protein, MMP2 Protein, anon-WO0118547.84 Protein, dm-2MMP Protein, dmmp2 Protein, l(2)02353 Protein, mmp2 Protein, wu:fa99h12 Protein, wu:fk89d01 Protein, fgmmp-2 Protein, Mmp-2 Protein, LOC100135793 Protein, Clg4a Protein, GelA Protein, MMP-2 Protein, CLG4 Protein, CLG4A Protein, MMP-II Protein, MONA Protein, TBE-1 Protein, matrix metallopeptidase 2 Protein, Matrix metalloproteinase 2 Protein, matrix metalloproteinase 2 Protein, matrix metalloproteinase-2 Protein, MMP2 Protein, Mmp2 Protein, mmp2 Protein, LOC657982 Protein, LOC100135793 Protein

Background:

Abbreviation: MMP-2

Target Synonym: 72 kDa Type IV Collagenase,72 kDa Gelatinase,Gelatinase A,Matrix Metalloproteinase-2,MMP-2,TBE-1,MMP2,CLG4A,CLG4,MMP-II,MONA,TBE-1

Background: Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.

Molecular Weight:

Calculated MW: 23.65 kDa

Observed MW: 30 kDa

UniProt: P08253

Pathways: Activation of Innate immune Response