ESM1 Protein (AA 20-184) (His tag)
-
- Target See all ESM1 Proteins
- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 20-184
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This ESM1 protein is labelled with His tag.
- Sequence
- Trp 20-Arg 184
- Characteristics
- A DNA sequence encoding the Human ESM1 protein (Q9NQ30) (Trp 20-Arg 184) was expressed with a N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product ESM1 Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
-
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
-
- Target
- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
- Alternative Name
- ESM1 (ESM1 Products)
- Synonyms
- ESM1 Protein, zgc:153027 Protein, 0610042H23Rik Protein, AV004503 Protein, ESM-1 Protein, Pg25 Protein, endocan Protein, endothelial cell specific molecule 1 Protein, endothelial cell-specific molecule 1 Protein, ESM1 Protein, esm1 Protein, Esm1 Protein
- Background
-
Abbreviation: ESM1
Target Synonym: Endocan,endothelial cell-specific molecule 1,ESM1,ESM-1,IGFBP-rp6
Background: ESM1 is a secreted protein which is produced by adipocytes. It has been noticed that ESM1 may play some role in obesity-associated vascular disease since circulating ESM-1 levels are reduced in the overweight and obese. ESM1 is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. Recently, ESM1 has been described as a specific biomarker of tip cells during neoangiogenesis. Its expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF or FGF-2. In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against ESM1.
- Molecular Weight
-
Calculated MW: 18.04 kDa
Observed MW: 25 kDa
- UniProt
- Q9NQ30
- Pathways
- Growth Factor Binding
-