MMP7 Protein (AA 95-267) (His tag)
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- Target See all MMP7 Proteins
- MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 95-267
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MMP7 protein is labelled with His tag.
- Sequence
- Tyr 95-Lys 267
- Characteristics
- A DNA sequence encoding the Human MMP-7 protein (P09237) (Tyr 95-Lys 267) was expressed with a N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product MMP7 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))
- Alternative Name
- MMP-7 (MMP7 Products)
- Synonyms
- MAT Protein, MPMM Protein, MMP-7 Protein, MPSL1 Protein, PUMP-1 Protein, matrilysin Protein, LOC727698 Protein, MMP7 Protein, Matrilysin Protein, matrix metallopeptidase 7 Protein, MMP7 Protein, Mmp7 Protein
- Background
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Abbreviation: MMP-7
Target Synonym: MMP-7,MPSL1,PUMP-1
Background: Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-7 (matrilysin) is expressed in epithelial cells of normal and diseased tissues, and is capable of digesting a large series of proteins of the extracellular matrix including collagen IV and X, gelatin, casein, laminin, aggrecan, entactin, elastin and versican. MMP-7 is implicated in the activation of other proteinases such as plasminogen, MMP-1, MMP-2, and MMP-9. In addition to its roles in connective tissue remodeling and cancer, MMP-7 also regulates intestinal alpha ?defensin activation in innate host defense, releases tumor necrosis factor-alpha in a model of herniated disc resorption, and cleaves FasL to generate a soluble form in a model of prostate involution. Structurally, MMP-7 is the smallest of the MMPs and consists of two domains: a pro-domain that is cleaved upon activation and a catalytic domain containing the zinc-binding site.
- Molecular Weight
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Calculated MW: 18.92 kDa
Observed MW: 20 kDa
- UniProt
- P09237
- Pathways
- Production of Molecular Mediator of Immune Response
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