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MASP1 Protein (AA 20-447) (His tag)

MASP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7505079
  • Target See all MASP1 Proteins
    MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 20-447
    Origin
    • 11
    • 4
    Human
    Source
    • 6
    • 5
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This MASP1 protein is labelled with His tag.
    Sequence
    His 20-Ala 447
    Characteristics
    A DNA sequence encoding the Human MASP1 protein (P48740) (His20-Ala447) was expressed with a N-His .
    Purity
    > 95 % as determined by reducing SDS-PAGE.
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  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Expiry Date
    12 months
  • Target
    MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))
    Alternative Name
    MASP1 (MASP1 Products)
    Synonyms
    AW048060 Protein, CCPII Protein, Crarf Protein, Masp1/3 Protein, 3MC1 Protein, CRARF Protein, CRARF1 Protein, MAP1 Protein, MASP Protein, MASP3 Protein, MAp44 Protein, PRSS5 Protein, RaRF Protein, mannan-binding lectin serine peptidase 1 Protein, mannan binding lectin serine peptidase 1 Protein, Masp1 Protein, MASP1 Protein
    Background

    Abbreviation: MASP1

    Target Synonym: Mannan-Binding Lectin Serine Protease 1,Complement Factor MASP-3,Mannose-Binding Lectin-Associated Serine Protease 1,MASP-1,RaRF,Serine Protease 5,MASP1,CRARF,CRARF1,PRSS5

    Background: Mannan-Binding Lectin Serine Protease 1 (MASP-1) belongs to the peptidase S1 family. MASP1 contains two CUB domains, one EGF-like domain, one peptidase S1 domain and two Sushi (CCP/SCR) domains. MASP1 is primarily expressed in liver. MASP1 involved in the lectin pathway of the complement, performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. MASP1 is synthesized as a zymogen and activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. MASP1 is not directly involved in complement activation but may act as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP2. MASP1 is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. MASP1 is inhibited by SERPING1 and A2M.

    Molecular Weight

    Calculated MW: 46.97 kDa

    Observed MW: 48 kDa

    UniProt
    P48740
    Pathways
    Complement System
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