BMP7 Protein (AA 293-431) (His tag)
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- Target See all BMP7 Proteins
- BMP7 (Bone Morphogenetic Protein 7 (BMP7))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 293-431
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This BMP7 protein is labelled with His tag.
- Sequence
- Ser 293-His 431
- Characteristics
- A DNA sequence encoding the Human BMP-7 protein (P18075) (Ser293-His431) was expressed with a N-His .
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product BMP7 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- BMP7 (Bone Morphogenetic Protein 7 (BMP7))
- Alternative Name
- BMP-7 (BMP7 Products)
- Synonyms
- bmp-7 Protein, bmp7 Protein, op-1 Protein, BMP7 Protein, zgc:153025 Protein, OP-1 Protein, OP1 Protein, BMP-7 Protein, fb83f09 Protein, wu:fb83f09 Protein, bone morphogenetic protein 7 Protein, bone morphogenetic protein 7, gene 1 L homeolog Protein, bone morphogenetic protein 7b Protein, bone morphogenetic protein 7, gene 2 L homeolog Protein, bone morphogenetic protein 7a Protein, BMP7 Protein, bmp7.1.L Protein, LOC100136282 Protein, bmp7b Protein, Bmp7 Protein, LOC100008826 Protein, bmp7.2.L Protein, bmp7a Protein
- Background
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Abbreviation: BMP-7
Target Synonym: Bone morphogenetic protein 7,BMP-7,Osteogenic protein 1,OP-1,Eptotermin alfa
Background: BMP-7 (Bone morphogenetic protein 7), also known as osteogenic protein 1 (OP-1), is a bone morphogenetic protein which belongs to the TGF-β superfamily. OP-1 is expressed in the brain, kidneys and bladder. BMP-7 may be involved in bone homeostasis. Osteogenic protein 1 plays a key role in the transformation of mesenchymal cells into bone and cartilage. The phosphorylation of SMAD1 and SMAD5 can be induced by BMP-7, which in turn induce transcription of numerous osteogenic genes. BMP-7 treatment can also induce all of the genetic markers of osteoblast differentiation in many cell types. The expression of BMP-7 causes ventral phenotypes while its complete inhibition creates a dorsal phenotype. Human recombinant BMP-7 protein can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma. It also functions in the treatment of tibial non-union, frequently in cases where a bone graft has failed. It is found that BMP7 has the potential for treatment of chronic kidney disease.
- Molecular Weight
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Calculated MW: 15.18 kDa
Observed MW: 15 kDa
- UniProt
- P18075
- Pathways
- Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance
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