Kallikrein 7 Protein (KLK7) (AA 23-253) (His tag)
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- Target See all Kallikrein 7 (KLK7) Proteins
- Kallikrein 7 (KLK7)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 23-253
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Kallikrein 7 protein is labelled with His tag.
- Sequence
- Glu 23-Arg 253
- Characteristics
- A DNA sequence encoding the Human KLK7 protein (P49862) (Glu23-Arg253) was expressed with a N-His .
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product KLK7 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- Kallikrein 7 (KLK7)
- Alternative Name
- KLK7 (KLK7 Products)
- Synonyms
- Prss6 Protein, SCCE Protein, PRSS6 Protein, hK7 Protein, kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Protein, kallikrein-related peptidase 7 Protein, kallikrein related peptidase 7 Protein, Klk7 Protein, KLK7 Protein
- Background
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Abbreviation: KLK7
Target Synonym: Kallikrein-7,hK7,Serine Protease 6,Stratum Corneum Chymotryptic Enzyme,hSCCE,KLK7,PRSS6,SCCE
Background: Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.
- Molecular Weight
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Calculated MW: 25.3 kDa
Observed MW: 31 kDa
- UniProt
- P49862
- Pathways
- Complement System
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