CPB2 Protein (AA 138-386) (His tag)

Catalog No. ABIN7505076

Product Details

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Protein Type: Recombinant

Protein Characteristics: AA 138-386

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CPB2 protein is labelled with His tag.

Sequence: Glu 138-Val 386

Characteristics: A DNA sequence encoding the Human TAFI protein (Q96IY4) (Glu138-Val386) was expressed with a N-His .

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))

Alternative Name: TAFI (CPB2 Products)

Synonyms: CPU Protein, PCPB Protein, TAFI Protein, 1110032P04Rik Protein, 4930405E17Rik Protein, AI255929 Protein, CPR Protein, Cpu Protein, pCPB Protein, zgc:112493 Protein, carboxypeptidase B2 Protein, carboxypeptidase B2 (plasma) Protein, CPB2 Protein, Cpb2 Protein, cpb2 Protein

Background:

Abbreviation: TAFI

Target Synonym: Carboxypeptidase B2,Carboxypeptidase U,CPU,Plasma Carboxypeptidase B,pCPB,Thrombin-Activable Fibrinolysis Inhibitor,TAFI,CPB2

Background: Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the plasma as a plasminogen-bound zymogen. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides, such as kinins or anaphylatoxins, in the circulation regulating their activities. CPB2 also down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. CPB2 exhibits carboxypeptidase activity when it is activated by proteolysis at residue Arg92 of the thrombin/thrombomodulin complex. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

Molecular Weight:

Calculated MW: 27.28 kDa

Observed MW: 32 kDa

UniProt: Q96IY4

Pathways: Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis