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IDE Protein (AA 753-973) (His tag)

IDE Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7505065
  • Target See all IDE Proteins
    IDE (Insulin-Degrading Enzyme (IDE))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 753-973
    Origin
    • 9
    • 3
    • 2
    Human
    Source
    • 5
    • 2
    • 2
    • 2
    • 2
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This IDE protein is labelled with His tag.
    Sequence
    Ala 753-Pro 973
    Characteristics
    A DNA sequence encoding the Human IDE protein (P14735) (Ala 753-Pro 973) was expressed with a N-His tag.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product IDE Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    Expiry Date
    12 months
  • Target
    IDE (Insulin-Degrading Enzyme (IDE))
    Alternative Name
    IDE (IDE Products)
    Synonyms
    zgc:162603 Protein, IDE Protein, 1300012G03Rik Protein, 4833415K22Rik Protein, AA675336 Protein, AI507533 Protein, INSDEGM Protein, INSULYSIN Protein, insulin degrading enzyme Protein, insulin-degrading enzyme Protein, metallopeptidase Protein, IDE Protein, ide Protein, LOC591315 Protein, CC1G_01115 Protein, Bm1_26615 Protein, PTRG_10875 Protein, SJAG_01430 Protein, EBI_21700 Protein, VDBG_06702 Protein, LOAG_08082 Protein, PGTG_04982 Protein, Tsp_00424 Protein, Ide Protein
    Background

    Abbreviation: IDE

    Target Synonym: Insulin-Degrading Enzyme,Abeta-Degrading Protease,Insulin Protease,Insulinase,Insulysin,IDE

    Background: Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted amyloid β-protein by neurons and microglia. IDE, which migrates at 110 kDa during gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF α and β-endorphin.

    Molecular Weight

    Calculated MW: 24.2 kDa

    Observed MW: 32 kDa

    UniProt
    P14735
    Pathways
    SARS-CoV-2 Protein Interactome
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