Prosaposin Protein (PSAP) (AA 17-524) (His tag)

Catalog No. ABIN7505051

Product Details

Target: Prosaposin (PSAP)

Protein Type: Recombinant

Protein Characteristics: AA 17-524

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Prosaposin protein is labelled with His tag.

Sequence: Gly 17-Asn 524

Characteristics: A DNA sequence encoding the Human PSAP protein (P07602) (Gly 17-Asn 524) was expressed with a N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Prosaposin (PSAP)

Alternative Name: PSAP (PSAP Products)

Synonyms: GLBA Protein, SAP1 Protein, AI037048 Protein, SGP-1 Protein, SGP1A Protein, cb759 Protein, wu:fa14a06 Protein, wu:fb36e02 Protein, wu:fb58g07 Protein, PSAP Protein, PSP-A Protein, SFTPA1B Protein, SP-A Protein, prosaposin Protein, surfactant protein A1 Protein, PSAP Protein, Psap Protein, psap Protein, LOC100011417 Protein, LOC100304726 Protein, LOC100526719 Protein, SFTPA1 Protein

Background:

Abbreviation: PSAP

Target Synonym: GLBA,SAP1p,PSAP,proactivator polypeptide,prosaposin,

Background: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Molecular Weight:

Calculated MW: 55.77 kDa

Observed MW: 45 kDa

UniProt: P07602

Pathways: Positive Regulation of Endopeptidase Activity