COL1A1 Protein (AA 1021-1109) (GST tag)
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- Target See all COL1A1 Proteins
- COL1A1 (Collagen, Type I, alpha 1 (COL1A1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1021-1109
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This COL1A1 protein is labelled with GST tag.
- Sequence
- Glu 1021-Gly 1109
- Characteristics
- A DNA sequence encoding the Human COL1A1 protein (P02452) (Glu1021-Gly1109) was expressed with a N terminal GST tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product COL1A1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- COL1A1 (Collagen, Type I, alpha 1 (COL1A1))
- Alternative Name
- Collagen alpha-1 chain (COL1A1 Products)
- Synonyms
- OI4 Protein, Col1a-1 Protein, Cola-1 Protein, Cola1 Protein, Mov-13 Protein, Mov13 Protein, COLIA1 Protein, col1a1 Protein, MGC52532 Protein, COL1A1 Protein, COL1A2 Protein, alpha1(I) Protein, cb21 Protein, sb:cb21 Protein, sb:cb384 Protein, wu:fa99c12 Protein, wu:fb02c06 Protein, alpha3(I) Protein, col1a3 Protein, hm:zeh0348 Protein, wu:fa95h05 Protein, wu:fd02a10 Protein, wu:fj59a10 Protein, collagen type I alpha 1 chain Protein, collagen, type I, alpha 1 Protein, collagen, type I, alpha 1 S homeolog Protein, collagen alpha-1(I) chain Protein, collagen type I alpha 2 chain Protein, collagen, type I, alpha 1a Protein, collagen 1a1 Protein, collagen, type I, alpha 1b Protein, COL1A1 Protein, Col1a1 Protein, col1a1.S Protein, LOC397571 Protein, COL1A2 Protein, col1a1a Protein, col1a1 Protein, col1a1b Protein
- Background
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Abbreviation: Collagen alpha-1 chain,COL1A1
Target Synonym: Collagen alpha-1(I) chain,Alpha-1 type I collagen,COL1A1,COL1A1
Background: Type I collagen is the most abundant structural protein of connective tissues such as skin, bone and tendon. It is synthesized as a procollagen molecule which is characterized by a 300 nm triple helical domain flanked by globular N- and C-terminal propeptides. The triple helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are frequently proline and hydroxyproline, respectively. The non-helical propeptides are removed by procollagen N- and C-proteinase activities so that the mature triple helices can self-assemble into collagen fibrils that provide tensile strength to tissues. Type I collagen is a heterotrimer that consists of two alpha 1(I) chains and one alpha 2(I) chain, although homotrimers consisting of three identical alpha 1(I) chains have also been described. This recombinant mini pro-alpha 1(I) collagen consists of a shortened alpha 1(I) chain with following domain structure from N- to C-terminus: N-propeptide, N?telopeptide, the 33 most N-terminal Gly-Xaa-Yaa repeats, the 33 most C-terminal Gly-Xaa-Yaa repeats, C-telopeptide and C-propeptide. The preparation contains a mixture of the full-length molecule, pN collagen I( alpha 1) and the C-terminal propeptide. This truncated pro-alpha 1(I) collagen is a substrate for procollagen N-proteinase and procollagen C-proteinase.
- Molecular Weight
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Calculated MW: 34.68 kDa
Observed MW: 35 kDa
- UniProt
- P02452
- Pathways
- Sensory Perception of Sound, Autophagy, Growth Factor Binding
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