GSK3 alpha Protein (AA 97-448)

Catalog No. ABIN7505000

Product Details

Target: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Protein Type: Recombinant

Protein Characteristics: AA 97-448

Origin: Human

Source: Escherichia coli (E. coli)

Sequence: Ser97-Pro448

Characteristics: A DNA sequence encoding the Human GSK3α Protein (P49840)(97-448)was expressed with a polyhistidine tag at the N-terminus.

Purity: > 80 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4., 5 % trehalose, 5 % mannitol, 0.01 % tween-80.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Alternative Name: GSK3alpha (GSK3a Products)

Synonyms: 2700086H06Rik Protein, GSK3A Protein, GSK-3[a] Protein, GSK-3[b] Protein, GSK3 Protein, gsk3a Protein, xgsk3 Protein, glycogen synthase kinase 3 alpha Protein, glycogen synthase kinase 3 alpha b Protein, glycogen synthase kinase 3 alpha S homeolog Protein, GSK3A Protein, Gsk3a Protein, gsk3a Protein, gsk3ab Protein, gsk3a.S Protein, Bm1_31380 Protein

Background:

Abbreviation: GSK3α

Target Synonym: Glycogen synthase kinase-3 alpha,GSK-3 alpha,Serine/threonine-protein kinase GSK3A,GSK3A

Background: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1.

Molecular Weight:

Calculated MW: 39.4 kDa

Observed MW: 39 kDa

UniProt: P49840

Pathways: PI3K-Akt Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, Warburg Effect