BIM Protein (AA 1-120) (His tag)
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- Target See all BIM (BCL2L11) Proteins
- BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-120
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This BIM protein is labelled with His tag.
- Sequence
- Met1-Arg120
- Characteristics
- Recombinant Human Bcl-2-like Protein 11 is produced by our E.coli expression system and the target gene encoding Met1-Arg120 is expressed with a 6His tag at the N-terminus.
- Purity
- > 90 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- <1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product BCL2L11 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4., 5 % trehalose, 5 % mannitol, 0.01 % tween-80.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
- Alternative Name
- BIM (BCL2L11 Products)
- Synonyms
- bim Protein, BAM Protein, BIM Protein, BOD Protein, 1500006F24Rik Protein, Bim Protein, Bod Protein, BimL Protein, BIMEL Protein, BCL2-like 11 Protein, BCL2 like 11 Protein, BCL2-like 11 (apoptosis facilitator) Protein, bcl2l11 Protein, BCL2L11 Protein, Bcl2l11 Protein
- Background
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Abbreviation: BIM,BCL2L11
Target Synonym: Bcl-2-like protein 11,Bcl2-L-11,Bcl2-interacting mediator of cell death,BCL2L11,BIM,BIML
Background: BIML is one of several splice variants of BIM, a proapoptotic protein belonging to the BH-3 domain-only subgroup of Bcl-2 family members. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BIML is thought to promote apoptosis by binding and inhibiting the activity of anti-apoptotic Bcl-2 family members, thereby inducing the release of cytochrome c from mitochondria. BIML is normally sequestered in an inactive conformation from anti-apoptotic Bcl-2 family members through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release BIML from microtubules to neutralize anti-apoptotic Bcl-2 family members, allowing for the initiation of apoptosis.
- Molecular Weight
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Calculated MW: 15 kDa
Observed MW: 15-18 kDa
- UniProt
- O43521-2
- Pathways
- PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity
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