FGG Protein (AA 25-444) (His tag)

Catalog No. ABIN7504915

Product Details

Target: FGG (Fibrinogen gamma Chain (FGG))

Protein Type: Recombinant

Protein Characteristics: AA 25-444

Origin: Cow

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This FGG protein is labelled with His tag.

Sequence: Tyr 25-Asp 444

Characteristics: A DNA sequence encoding the Bovine FGG protein (P12799) (Tyr 25-Asp 444) was expressed with N-His tag.

Purity: > 95 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: FGG (Fibrinogen gamma Chain (FGG))

Alternative Name: FGG (FGG Products)

Synonyms: FXII Protein, HAF Protein, 3010002H13Rik Protein, AI256424 Protein, fibrinogen Protein, FGG Protein, LOC100220680 Protein, fb60h05 Protein, fb62e01 Protein, wu:fb60h05 Protein, wu:fb62e01 Protein, zgc:56023 Protein, fibrinogen gamma chain Protein, coagulation factor XII (Hageman factor) Protein, fibrinogen gamma chain L homeolog Protein, FGG Protein, F12 Protein, fgg Protein, Fgg Protein, fgg.L Protein, CpipJ_CPIJ006387 Protein, CpipJ_CPIJ010087 Protein

Background:

Abbreviation: FGG,Fibrinogen gamma chain

Target Synonym: FIBG,Fibrinogen gamma chain,fibrinogen gamma-b chain

Background: Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Molecular Weight:

Calculated MW: 46.09 kDa

Observed MW: 50 kDa

UniProt: P12799