S100A7 Protein (AA 2-101) (His tag)
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- Target See all S100A7 Proteins
- S100A7 (S100 Calcium Binding Protein A7 (S100A7))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-101
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Origin
- Cow
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This S100A7 protein is labelled with His tag.
- Sequence
- Ser 2-Gln 101
- Characteristics
- A DNA sequence encoding the Bovine S100A7 protein (Q28050) (Ser 2-Gln 101) was expressed with N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product S100A7 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- S100A7 (S100 Calcium Binding Protein A7 (S100A7))
- Alternative Name
- S100A7 (S100A7 Products)
- Synonyms
- PSOR1 Protein, S100A7c Protein, S100A7 Protein, S100 calcium binding protein A7 Protein, protein S100-A7 Protein, S100A7 Protein, LOC469501 Protein, LOC713189 Protein, LOC714943 Protein, LOC101104285 Protein, LOC102191570 Protein
- Background
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Abbreviation: S100A7,PSOR1
Target Synonym: Protein S100-A7,Psoriasin,S100 calcium-binding protein A7,S100A7,PSOR1,S100A7C
Background: S100A7 is a 11-12 kDa member of the S100 family of EF hand calcium binding proteins. Human S100A7 shares 32 % amino acid sequence identity with mouse S100A7A, the closest related protein in mouse. It is acetylated at the N-terminus and binds both calcium and zinc ions. S100A7 is up-regulated in keratinocytes of psoriasis and atopic dermatitis lesions, as well as in epithelial cells of the tongue, eye, and female genital tract. Its up-regulation can be induced by bacterial exposure, inflammatory cytokines, or epidermal barrier disruption. S100A7 supports epithelial integrity through killing E. coli by sequestration of zinc and through inducing the up-regulation of tight junction proteins. The interaction of S100A7 with RAGE promotes the migration of immune cells and the infiltration of macrophages into tumor sites.
- Molecular Weight
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Calculated MW: 10.89 kDa
Observed MW: 12 kDa
- UniProt
- Q28050
- Pathways
- S100 Proteins
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