TNFRSF1B Protein (AA 23-257) (Fc Tag)
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- Target See all TNFRSF1B Proteins
- TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 23-257
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TNFRSF1B protein is labelled with Fc Tag.
- Purpose
- Human TNFR2/CD120b/TNFRSF1B Protein
- Sequence
- Leu23-Asp257
- Characteristics
- Recombinant Human TNFR2/CD120b/TNFRSF1B Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Leu23-Asp257.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product TNFRSF1B Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))
- Alternative Name
- TNFR2 (TNFRSF1B Products)
- Synonyms
- CD120b Protein, TBPII Protein, TNF-R-II Protein, TNF-R75 Protein, TNFBR Protein, TNFR1B Protein, TNFR2 Protein, TNFR80 Protein, p75 Protein, p75TNFR Protein, TNF-RII/TNFRSF1B Protein, TNFR-II Protein, TNFRSF1B Protein, TNF-R2 Protein, TNF-alphaR2 Protein, TNFRII Protein, TNFalpha-R2 Protein, Tnfr-1 Protein, Tnfr2 Protein, rank Protein, zgc:163064 Protein, TNF receptor superfamily member 1B Protein, tumor necrosis factor receptor superfamily, member 1b Protein, tumor necrosis factor receptor superfamily, member 1B Protein, TNFRSF1B Protein, Tnfrsf1b Protein, tnfrsf1b Protein
- Background
- Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
- Molecular Weight
- 51.89 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.
- Pathways
- NF-kappaB Signaling, Apoptosis, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Ubiquitin Proteasome Pathway
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