p53 Protein (AA 25-305, Tetramer) (PE)
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- Target See all p53 (TP53) Proteins
- p53 (TP53) (Tumor Protein P53 (TP53))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 25-305, Tetramer
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This p53 protein is labelled with PE.
- Purpose
- PE-Labeled Human HLA-A*02:01 & B2M & P53 WT (HMTEVVRRC) Tetramer Protein
- Sequence
- Gly25-Thr305 (HLA-A*02:01),Ile21-Met119 (B2M) and HMTEVVRRC peptide
- Specificity
- Uni-Prot: A0A140T913 (HLA-A*02:01), P61769 (B2M), HMTEVVRRC
- Characteristics
- Recombinant PE-Labeled Human HLA-A*02:01 & B2M & P53 WT (HMTEVVRRC) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. PE-Labeled Human HLA-A*02:01 & B2M & P53 WT (HMTEVVRRC) Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin. It contains Gly25-Thr305(HLA-A*02:01),Ile21-Met119(B2M) and HMTEVVRRC peptide.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product TP53 Protein
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Tumor Protein P53 (TP53) (AA 1-393) protein (GST tag)
TP53 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Protein P53 (TP53) (Active) protein (His tag)TP53 Origin: Human Host: Escherichia coli (E. coli) Recombinant STD, PI, in vitro Active
Tumor Protein P53 (TP53) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)TP53 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining STD, AbP
Tumor Protein P53 (TP53) (AA 1-391) protein (His tag)TP53 Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Tumor Protein P53 (TP53) (AA 94-201) protein (GST tag)TP53 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Protein P53 (TP53) protein (His-SUMO Tag)TP53 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90% as determined by SDS-PAGE. ELISA
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as 0.22μm filtered solution in PBS, 0.2 % BSA ( pH 7.4).
- Storage
- -80 °C
- Storage Comment
- Valid for 6 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles and protect from light.
- Expiry Date
- 12 months
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- Target
- p53 (TP53) (Tumor Protein P53 (TP53))
- Alternative Name
- P53 (TP53 Products)
- Synonyms
- BCC7 Protein, LFS1 Protein, P53 Protein, TRP53 Protein, p53 Protein, Trp53 Protein, brp53 Protein, drp53 Protein, etID22686.5 Protein, fb40d06 Protein, wu:fb40d06 Protein, zgc:111919 Protein, Tp53 Protein, bbl Protein, bfy Protein, bhy Protein, p44 Protein, tp53 Protein, Xp53 Protein, TP53 Protein, tumor protein p53 Protein, cellular tumor antigen p53 Protein, transformation related protein 53 Protein, tumor protein p53 L homeolog Protein, TP53 Protein, CpipJ_CPIJ002758 Protein, Tp53 Protein, tp53 Protein, Trp53 Protein, tp53.L Protein
- Background
- P53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
- UniProt
- A0A140T913
- Pathways
- p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
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