Oncostatin M Receptor Protein (OSMR) (AA 28-740) (Fc Tag)
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- Target See all Oncostatin M Receptor (OSMR) Proteins
- Oncostatin M Receptor (OSMR)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 28-740
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Oncostatin M Receptor protein is labelled with Fc Tag.
- Purpose
- Human OSMR Protein
- Sequence
- Glu28-Met740
- Characteristics
- Recombinant Human OSMR Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Glu28-Met740.
- Purity
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product OSMR Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as 0.22 μm filtered solution in PBS ( pH 7.4).
- Storage
- -80 °C
- Storage Comment
- Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- Oncostatin M Receptor (OSMR)
- Alternative Name
- OSMR (OSMR Products)
- Synonyms
- OSMRB Protein, PLCA1 Protein, oncostatin M receptor Protein, OSMR Protein, Osmr Protein
- Background
- OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.
- Molecular Weight
- 107.06 kDa. Due to glycosylation, the protein migrates to 120-140 kDa based on Tris-Bis PAGE result.
- Pathways
- JAK-STAT Signaling, Growth Factor Binding
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