CEACAM5 Protein (AA 35-685) (Biotin)

Catalog No. ABIN7504291

Product Details

Target: CEACAM5 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5))

Protein Type: Recombinant

Protein Characteristics: AA 35-685

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CEACAM5 protein is labelled with Biotin.

Purpose: Biotinylated Human CEACAM-5/CD66e Protein

Sequence: Lys35-Ala685

Characteristics: Recombinant Biotinylated Human CEACAM-5/CD66e Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Lys35-Ala685.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in 20 mM PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: CEACAM5 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5))

Alternative Name: CEACAM-5 (CEACAM5 Products)

Synonyms: CD66e Protein, CEA Protein, CEACAM5 Protein, CEACAM Protein, 1600029H12Rik Protein, Psg30 Protein, carcinoembryonic antigen related cell adhesion molecule 5 Protein, carcinoembryonic antigen Protein, carcinoembryonic antigen-related cell adhesion molecule 5 Protein, carcinoembryonic antigen-related cell adhesion molecule 8 Protein, carcinoembryonic antigen gene family Protein, CEACAM5 Protein, Ceacam5 Protein, LOC100409241 Protein, Cea Protein

Background: Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated.

Molecular Weight: 74.23 kDa. Due to glycosylation, the protein migrates to 110-150 kDa based on Tris-Bis PAGE result.