CCR7 Protein (AA 1-378) (His tag)

Catalog No. ABIN7504254

Product Details

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Protein Type: Recombinant

Protein Characteristics: AA 1-378

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CCR7 protein is labelled with His tag.

Purpose: Human CCR7 (nanodisc) Protein

Sequence: Met1-Pro378

Characteristics: Recombinant Human CCR7 (nanodisc) Protein is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Pro378.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as 0.22 μm filtered solution in PBS ( pH 7.4).

Storage: -80 °C

Storage Comment: Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Alternative Name: CCR7 (CCR7 Products)

Synonyms: zgc:165629 Protein, ccr7-a Protein, CD197 Protein, Cdw197 Protein, Cmkbr7 Protein, EBI1 Protein, Ebi1h Protein, BLR2 Protein, CDw197 Protein, CMKBR7 Protein, chemokine (C-C motif) receptor 7 Protein, C-C motif chemokine receptor 7 Protein, C-C motif chemokine receptor 7 L homeolog Protein, ccr7 Protein, CCR7 Protein, ccr7.L Protein, Ccr7 Protein

Background: CC-chemokine receptor 7 (CCR7), collaborated with its ligands CCL19 and CCL21, controls extensive migratory events in the immune system. CCR7-bearing dendritic cells can swarm into T-cell zones in lymph nodes, initiating the antigen presentation and T-cell response. Abnormal expression of CCR7 in dendritic cells will cause a series of inflammatory diseases due to the chaotic dendritic cell trafficking.

Molecular Weight: 67.70 kDa.

UniProt: P32248

Pathways: Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process