APCDD1 Protein (AA 27-492)

Catalog No. ABIN7504233

Product Details

Target: APCDD1 (Adenomatosis Polyposis Coli Down-Regulated 1 (APCDD1))

Protein Type: Recombinant

Protein Characteristics: AA 27-492

Origin: Human

Source: HEK-293 Cells

Purpose: Human APCDD1 Protein

Sequence: Leu27-His492

Characteristics: Recombinant Human APCDD1 Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Leu27-His492.

Purity: > 95 % as determined by Tris-Bis PAGE

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: APCDD1 (Adenomatosis Polyposis Coli Down-Regulated 1 (APCDD1))

Alternative Name: APCDD1 (APCDD1 Products)

Synonyms: drapc1 Protein, xPgo Protein, APCDD1 Protein, Pgo1 Protein, cAPCDD1 Protein, B7323 Protein, DRAPC1 Protein, HHS Protein, HTS Protein, AB023957 Protein, AU041258 Protein, Drapc1 Protein, EIG180 Protein, adenomatosis polyposis coli down-regulated 1 Protein, APC down-regulated 1 Protein, adenomatosis polyposis coli down-regulated 1 L homeolog Protein, apcdd1 Protein, APCDD1 Protein, Apcdd1 Protein, apcdd1.L Protein

Background: Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. In situ hybridization showed that Apcdd1 was expressed in the condensed mesenchyme at the bud stage, and in the inner enamel epithelium (IEE), including enamel knot (EK) at the cap stage. APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating the epithelial rearrangement in the IEE.

Molecular Weight: 80.06 kDa. Due to glycosylation, the protein migrates to 82-110 kDa based on Tris-Bis PAGE result.

UniProt: Q8J025