Klotho beta Protein (KLB) (His tag)
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- Target See all Klotho beta (KLB) Proteins
- Klotho beta (KLB)
- Protein Type
- Recombinant
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Origin
- Rat
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Klotho beta protein is labelled with His tag.
- Purpose
- Rat Klotho beta / KLB Protein, His Tag
- Sequence
- Phe 53 - Pro 994
- Characteristics
- Rat Klotho beta, His Tag is expressed from human 293 cells (HEK293). It contains AA Phe 53 - Pro 994 (Accession # D3Z8T6-1).
- Purity
- 90 %
- Endotoxin Level
- 1.0 EU per μg
- Top Product
- Discover our top product KLB Protein
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Klotho beta (KLB) protein (His tag)
KLB Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Klotho beta (KLB) (AA 53-994) protein (His tag)KLB Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Klotho beta (KLB) proteinKLB Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, ELISA, IP
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- Comment
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This protein carries a polyhistidine tag at the C-terminus. (10xHis) The protein has a calculated MW of 110.5 kDa. The protein migrates as 130-145 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
- Storage Comment
- -20°C
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- Target
- Klotho beta (KLB)
- Alternative Name
- Klotho beta (KLB Products)
- Synonyms
- KLB Protein, BKL Protein, AV071179 Protein, betaKlotho Protein, Klb-ps1 Protein, RGD1308227 Protein, klotho beta Protein, KLB Protein, Klb Protein
- Background
- KLB (Klotho Beta) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding. An important paralog of this gene is KL. Klotho Beta is a regulator in multiple metabolic processes, while its role in cancer remains unclear. We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues. Hepatoma cells also showed decreased expression of βKlotho compared with normal hepatocyte cells. Reintroduction of βKlotho into hepatoma cells inhibited their proliferation.
- Molecular Weight
- 110.5 kDa
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Growth Factor Binding
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