IL12RB2 Protein (His tag)
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- Target See all IL12RB2 Proteins
- IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL12RB2 protein is labelled with His tag.
- Purpose
- Human IL-12 R beta 2 Protein, His Tag (MALS verified)
- Sequence
- Lys 24 - Asn 622
- Characteristics
- Human IL-12 R beta 2, His Tag is expressed from human 293 cells (HEK293). It contains AA Lys 24 - Asn 622 (Accession # Q99665-1).
- Purity
- 95 %
- Endotoxin Level
- 1.0 EU per μg
- Grade
- MALS verified
- Top Product
- Discover our top product IL12RB2 Protein
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Interleukin 12 Receptor, beta 2 (IL12RB2) protein (Fc Tag)
IL12RB2 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Interleukin 12 Receptor, beta 2 (IL12RB2) (AA 105-214) protein (GST tag)IL12RB2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 12 Receptor, beta 2 (IL12RB2) (AA 1-862) protein (GST tag)IL12RB2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 12 Receptor, beta 2 (IL12RB2) (Active) protein (His tag)IL12RB2 Origin: Mouse Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
Interleukin 12 Receptor, beta 2 (IL12RB2) (AA 24-622), (Extracellular) protein (His tag)IL12RB2 Origin: Human Host: Yeast Recombinant > 90 % SDS
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- Comment
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This protein carries a polyhistidine tag at the C-terminus. (10xHis) The protein has a calculated MW of 70.0 kDa. The protein migrates as 66 kDa and 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
- Storage Comment
- -20°C
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- Target
- IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))
- Alternative Name
- IL-12 R beta 2 (IL12RB2 Products)
- Synonyms
- IL12RB2 Protein, A930027I18Rik Protein, IL-12RB2 Protein, Ifnm Protein, interleukin 12 receptor subunit beta 2 Protein, interleukin 12 receptor, beta 2 Protein, IL12RB2 Protein, Il12rb2 Protein
- Background
- The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12RB2 is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. IL-12B2 gene acts as tumor suppressor in human acute and chronic B-cell leukemias/lymphomas, IL-12R beta 2 directly restrains multiple myeloma cell growth, and targeting of IL-12 to tumor cells holds promise as new therapeutic strategy.
- Molecular Weight
- 70.0 kDa
- Pathways
- JAK-STAT Signaling
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